OUR SCIENCE

UNLOCKING THE THERAPEUTIC POTENTIAL OF AAT

Alpha-1 antitrypsin (AAT) is a human serine protease inhibitor (SERPIN) essential for tissue protection from damage by proteases. It has immuno-modulatory functions and provides broadband antiviral and bacteriostatic effects. We have validated these therapeutic effects and are developing our AAT products for airway inflammatory diseases, respiratory viral and bacterial infections and further diseases.

OVERCOMING AAT SCARCITY

AAT products are currently only used for augmentation therapy in AAT deficiency, a severe genetic disorder. These products are exclusively produced from human plasma, making them a scarce and expensive resource. We have established an industrial recombinant manufacturing process, overcoming the limitations of plasma AAT production and ensuring consistent quality, thereby fully unlocking the therapeutic potential of AAT.

AAT INHALATION FOR EFFECTIVE DRUG DELIVERY TO THE AIRWAYS

The treatment of respiratory diseases requires drug delivery directly to the respiratory tract for optimal local effect. We utilize protein formulation technology combined with cutting-edge inhalation technology of therapeutic proteins for safe, effective and convenient drug application. User-friendly handheld inhalers are under development and will allow for broad and cost-effective use.

A VERSATILE PLATFORM FOR A RANGE OF DISEASES

We develop AAT products for a range of indications by a modular product approach, consisting of several formulations and application devices. For efficient product development, matching the needs of our target indications. Our products are covered by a portfolio of own IP.